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Muscle-Specific Promoters for Gene Therapy

1 year ago - This review focuses on the development and improvement of muscle-specific promoters based on skeletal muscle α-actin, muscle creatine kinase, and desmin genes, as well as other genes expressed in ......detail

So-Called Junk DNA – Genetic “Dark Matter” – Is Actually Critical to Survival in Mammals

So-Called Junk DNA – Genetic “Dark Matter” – Is Actually Critical to Survival in Mammals5 days ago - Knocking out transposon promoter leads to pup death in mice; similar promoters found in many mammals. Nearly half of our DNA has been written off as junk, the discards of evolution: sidelined or ......detail

Inducing gene expression by targeting promoter sequences using small activating RNAs

2 months ago - In some cases, certain areas of a gene promoter support ‘hotspots’ in which several ... for growth inhibition so cell content at time of harvest roughly equals those found in control treatments....detail

Gene Silencing in Cancer in Association with Promoter Hypermethylation

13 days ago - 97,120,121 Thus, it is critical to know the position of promoter hypermethylation for every candidate gene in the context of the progression of a given tumor type. It is also essential to study ......detail

Types of Gene Regulation

12 years ago - Several structural genes ONE promoter and one terminator A control site (operator ... and stops rapidly after the addition of glucose. See and study Fig. 16.5 and 16.7 to see how the normal lac operon ......detail

Evolution of Brain Active Gene Promoters in Human Lineage Towards the Increased Plasticity of Gene Regulation.

3 years ago - We hypothesize that this feature can be explained by evolutionary changes in gene promoters active in the brain prefrontal cortex leading to a more flexible gene regulation network. The ......detail

Operator gene

6 years ago - protein that binds to the operator region, which is another short segment of DNA found between the promoter and the structural genes. The regulator protein can either block transcription, in which ......detail

The (−765 G→C) promoter variant of the COX-2/PTGS2 gene is associated with a lower risk for end-stage hip and knee osteoarthritis

3 years ago - Conclusion The promoter polymorphism rs20417 of the COX-2 gene contributes to the genetic risk for end ... For unilateral OA an association with the rs20417 genotype could not be found (table 2)....detail

Genetics of Atopy and Asthma: The Rationale behind Promoter-based Candidate Gene Studies (IL-4 and IL-10)

4 years ago - The candidate gene approach has been applied to the promoter region of a number of cytokine genes, both within and outside of the human 5q33 cytokine gene cluster. As a prototype for both cytokines, ......detail

Subset of autism cases linked to mutations in noncoding genome

Subset of autism cases linked to mutations in noncoding genome5 days ago - Autism involves mutations in noncoding portions of the genome in at least 3 percent of people with the condition. The mutations occur in regions that help regulate known autism-linked genes....detail

−429T/C and −374T/A Polymorphisms of RAGE Gene Promoter Are Not Associated With Diabetic Retinopathy in Chinese Patients With Type 2 Diabetes

2 years ago - No differences were found between the diabetic and nondiabetic subjects ... Our study indicates that the −429T/C and −374T/A polymorphisms in RAGE gene promoters are not associated with diabetic ......detail

O-6-methylguanine-DNA methyltransferase gene promoter methylation and lung cancer risk: A meta-analysis.

3 years ago - MATERIALS AND METHODS: We electronic searched the MEDLINE and CNKI databases to find the open published studies related to MGMT gene promoter hypermethylation in NSCLC patients. The odds ratio (OR) ......detail

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